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P-gp


P-gp (permeability glycoprotein) is an important protein of the cell membrane that pumps many foreign substances out of cells. It is an ATP-dependent efflux pump with broad substrate specificity. It exists in animals, fungi and bacteria and likely evolved as a defense mechanism against harmful substances. P-gp is a glycoprotein that in humans is encoded by the ABCB1 gene. P-gp is a well-characterized ABC-transporter (which transports a wide variety of substrates across extra- and intracellular membranes) of the MDR/TAP subfamily.

  • SC144 EY0799

    SC144是一种口服有效的小分子gp130抑制剂。

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  • LDN-193189 HCl EY0743

    LDN193189 HCl是LDN193189的盐酸盐,这是一种选择性BMP信号抑制剂,它能抑制BMP type I receptors ALK2和ALK3的转录活性，其 IC50 为 5 nM 和 30 nM, 并且对于BMP的选择性是对TGF-β选择性的200倍。

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  • Tariquidar EY0593

    Tariquidar (XR9576)是非竞争性P-gp抑制剂，Kd为5.1 nM，可逆转药物抗性在MDR细胞中。

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  • Fulvestrant EY0536

    Fulvestrant是一种Estrogen receptor（ER）（雌激素受体）拮抗剂， IC50为0.094 nM。

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  • LDK378 EY0511

    LDK378(Ceritinib)是ALK抑制剂，IC50为0.2 nM，比对IGF-1R和InsR的抑制性高40倍和35倍。

    More

  • SC144 EY0799

    SC144是一种口服有效的小分子gp130抑制剂。

    More

  • LDN-193189 HCl EY0743

    LDN193189 HCl是LDN193189的盐酸盐,这是一种选择性BMP信号抑制剂,它能抑制BMP type I receptors ALK2和ALK3的转录活性，其 IC50 为 5 nM 和 30 nM, 并且对于BMP的选择性是对TGF-β选择性的200倍。

    More

  • Tariquidar EY0593

    Tariquidar (XR9576)是非竞争性P-gp抑制剂，Kd为5.1 nM，可逆转药物抗性在MDR细胞中。

    More

  • Fulvestrant EY0536

    Fulvestrant是一种Estrogen receptor（ER）（雌激素受体）拮抗剂， IC50为0.094 nM。

    More

  • LDK378 EY0511

    LDK378(Ceritinib)是ALK抑制剂，IC50为0.2 nM，比对IGF-1R和InsR的抑制性高40倍和35倍。

    More
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