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Oct-4


Oct-4 transcription factor(Oct3/4,POU5F1) is initially active as a maternal factor in the oocyte but remains active in embryos throughout the preimplantation period. Oct-4 expression is associated with an undifferentiated phenotype and tumors. Gene knockdown of Oct-4 promotes differentiation, thereby demonstrating a role for these factors in human embryonic stem cell self-renewal. Oct-4 can form a heterodimer with Sox2, so that these two proteins bind DNA together.

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    BIBR 1532是非竞争性端粒酶抑制剂，IC50为100 nM。

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  • Chlorpromazine HCl EY0667

    Chlorpromazine hydrochloride (盐酸氯丙嗪) 是多巴胺受体和钾离子通道抑制剂。

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    TTNPB 是RAR激动剂，对人RARα，β和γ的IC50分别为5.1 nM，4.5 nM和9.3 nM。

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  • PF-562271 EY0368

    PF-562271, which is a potent ATP-competitive Pyk2/FAK dual inhibitor, has completed phase I clinical trial and is considered to be a promising drug for patients with solid tumors. PF-562271是一种有效的，ATP竞争性的，可逆的FAK抑制剂，IC50为1.5 nM，作用于Pyk2比作用于FAK选择性低10倍左右，比作用于其他蛋白激酶（除了一些CDKs）选择性高100倍以上。

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  • OAC1 EY0349

    OAC1是转录因子Oct4活化剂，提高iPSC的重编程效率和编程过程中的加速。

    More

  • BIBR1532 EY1683

    BIBR 1532是非竞争性端粒酶抑制剂，IC50为100 nM。

    More

  • Chlorpromazine HCl EY0667

    Chlorpromazine hydrochloride (盐酸氯丙嗪) 是多巴胺受体和钾离子通道抑制剂。

    More

  • TTNPB EY0475

    TTNPB 是RAR激动剂，对人RARα，β和γ的IC50分别为5.1 nM，4.5 nM和9.3 nM。

    More

  • PF-562271 EY0368

    PF-562271, which is a potent ATP-competitive Pyk2/FAK dual inhibitor, has completed phase I clinical trial and is considered to be a promising drug for patients with solid tumors. PF-562271是一种有效的，ATP竞争性的，可逆的FAK抑制剂，IC50为1.5 nM，作用于Pyk2比作用于FAK选择性低10倍左右，比作用于其他蛋白激酶（除了一些CDKs）选择性高100倍以上。

    More

  • OAC1 EY0349

    OAC1是转录因子Oct4活化剂，提高iPSC的重编程效率和编程过程中的加速。

    More
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