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Ion Pumps/Transporters


Ion pumps/transporters are transmembrane proteins that allow ion flux across biological membranes against their concentration gradient. Ion pumps require energy usually from ATP hydrolysis, whilst exchangers use the energy established by the concentration gradient of another ion. They belong to the ATPase and solute carrier families and are important for maintaining the correct concentrations of various ions within the appropriate subcellular and intercellular compartments. Ion pumps/transporters include:
Ca2+-ATPase ;    H+,K+-ATPase;    H+-ATPase;    K+/Cl- Cotransporter 2 ;   Monocarboxylate Transporters;
Na+/Ca2+ Exchanger ;   Na+/H+ Exchanger ;   Na+/K+ ATPase ;   Na+/K+/Cl- Symporter.

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    GBR 12783 dihydrochloride是活性选择性 dopamine uptake inhibitor（摄取抑制剂）。

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  • Furosemide EI1154

    Furosemide是Na+/2Cl-/K+ (NKCC) symporter 抑制剂。 也是 GABAA的拮抗剂。

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  • Flupenthixol dihydrochloride EI1131

    Flupenthixol dihydrochloride是Dopamine 受体拮抗剂。

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  • Fenoldopam hydrochloride EI1112

    Fenoldopam hydrochloride是选择性 D1样部分激动剂。

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  • Fananserin EI1108

    Fananserin是5-HT2A 拮抗剂。 也是D4 拮抗剂。

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