Gardos Channel
Gardos Channel (Potassium intermediate/small conductance calcium-activated channel, subfamily N,KCNN4) is a human gene encoding the KCa3.1 protein. The KCa3.1 protein is part of a potentially heterotetrameric voltage-independent potassium channel that is activated by intracellular calcium. Activation is followed by membrane hyperpolarization, which promotes calcium influx. The encoded protein may be part of the predominant calcium-activated potassium channel in T-lymphocytes. This gene is similar to other KCNN family potassium channel genes, but it differs enough to possibly be considered as part of a new subfamily.
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Panobinostat (LBH589)是一种新型的，广谱的HDAC抑制剂，IC50为5 nM。
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RGFP966是一种HDAC抑制剂，作用于HDAC3的IC50为0.08μM ，比作用于其他HDAC选择性高200倍以上。
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AR-42 is a novel HDAC inhibitor with an IC50 of 0.61 μM for acute lymphoblastic leukemia (697) cell lines.
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Geldanamycin是HSP90抑制剂，Kd为1.2 μM。
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Tubastatin A是一种有效的，选择性HDAC6抑制剂，IC50为15 nM，除了HDAC8(57倍)外，选择性作用于所有其他同工酶(1000倍)。
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