Gardos Channel
Gardos Channel (Potassium intermediate/small conductance calcium-activated channel, subfamily N,KCNN4) is a human gene encoding the KCa3.1 protein. The KCa3.1 protein is part of a potentially heterotetrameric voltage-independent potassium channel that is activated by intracellular calcium. Activation is followed by membrane hyperpolarization, which promotes calcium influx. The encoded protein may be part of the predominant calcium-activated potassium channel in T-lymphocytes. This gene is similar to other KCNN family potassium channel genes, but it differs enough to possibly be considered as part of a new subfamily.
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AUY922 (NVP-AUY922)是高活性HSP90α和β抑制剂，IC50为13 nM和21 nM，对GRP94和 TRAP-1的活性较低。
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RG2833(RGFP109)是可通过血脑屏障的HDAC抑制剂，对HDAC1和HDAC3的IC50分别为60nM和50nM。
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MGCD0103 (Mocetinostat)是HDAC抑制剂，对HDAC 1，HDAC 2和HDAC 3的IC50分别为0.15，0.29和1.66 μM。
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Sodium Butyrate (丁酸钠) 被报道证实为HDAC抑制剂，从而导致组蛋白过乙酰化。
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PCI-34051是高活性的HDAC8特异性抑制剂，IC50为10 nM，比对其它HDAC亚型的抑制性高200倍以上。
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