E2 enzymes
E2 enzymes (Ubiquitin-conjugating enzymes) perform the second step in the ubiquitination reaction that targets a protein for degradation via the proteasome.The ubiquitination process covalently attaches ubiquitin, a short protein of 76 amino acids, to a lysine residue on the target protein. Once a protein has been tagged with one ubiquitin molecule, additional rounds of ubiquitination form a polyubiquitin chain that is recognized by the proteasome's 19S regulatory particle, triggering the ATP-dependent unfolding of the target protein that allows passage into the proteasome's 20S core particle, where proteases degrade the target into short peptide fragments for recycling by the cell.
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Sertraline hydrochloride (盐酸舍曲林) 是选择性5羟色胺再吸收抑制剂（SSRI）。
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Fluoxetine hydrochloride是选择性5羟色胺再吸收抑制剂（SSRI）。
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Agomelatine是人和猪的5-HT2C受体竞争性拮抗剂，pKi分别为6.2和6.4。
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Disulfiram是氨基甲酸酯衍生物，可作用于多巴胺-β-羟化酶。
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Mirtazapine是抗抑郁的5-HT受体抑制剂。
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