E2 enzymes
E2 enzymes (Ubiquitin-conjugating enzymes) perform the second step in the ubiquitination reaction that targets a protein for degradation via the proteasome.The ubiquitination process covalently attaches ubiquitin, a short protein of 76 amino acids, to a lysine residue on the target protein. Once a protein has been tagged with one ubiquitin molecule, additional rounds of ubiquitination form a polyubiquitin chain that is recognized by the proteasome's 19S regulatory particle, triggering the ATP-dependent unfolding of the target protein that allows passage into the proteasome's 20S core particle, where proteases degrade the target into short peptide fragments for recycling by the cell.
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Loxapine Succinate是一种D2DR和D4DR抑制剂，血清素激活受体拮抗剂，也是一种苯氧氮平类抗精神病药。
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Clomipramine hydrochloride 是5-羟色胺转运体（SERT）、去甲肾上腺素转运体（NET）和多巴胺转运体（DAT）阻断剂，Ki分别为0.14，54和3 nM。
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Clarithromycin 是一种大环内酯类抗生素，是CYP3A4抑制剂。
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Almotriptan malate是5-HT1B/1D受体激动剂，可作用于偏头疼。
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WAY-100635 Maleate是一种有效的，选择性的5-HT1A受体激动剂，pIC50为8.87，比作用于其他5-HT受体亚型和主要的神经递质受体选择性高100倍以上。
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