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Muromonab CD3 (OKT3), the murine anti-CD3 monoclonal antibody of the IgG-2a class, used as a powerful immunosuppressive agent in solid organ transplantation and the first-line treatment of acute allograft rejection.
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Natalizumab is a humanized monoclonal antibody against α4 integrins highly effective in relapsing-remitting multiple sclerosis (MS).
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Efalizumab, a recombinant humanized monoclonal IgG1 antibody directed against a subunit (CD11a) of leukocyte function-associated antigen-1 (LFA-1), inhibits the T cell activation, migration and adhesion to keratinocytes.
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Etanercept, a TNFα receptor Fc fusion protein that binds to IgG1, is used for the treatment of rheumatic disease and psoriasis.
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Evolocumab (Repatha, AMG 145) is a fully human monoclonal antibody against PCSK9, significantly reduces low-density lipoprotein-cholesterol (LDL-C) levels.
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