Apoptosis Inducer
Apoptosis inducing factor is involved in initiating a caspase-independent pathway of apoptosis by causing DNA fragmentation and chromatin condensation. It also acts as an NADH oxidase. Another AIF function is to regulate the permeability of the mitochondrial membrane upon apoptosis. Normally it is found behind the outer membrane of the mitochondria and is therefore secluded from the nucleus. However, when the mitochondrion is damaged, it moves to the cytosol and to the nucleus. Inactivation of AIF leads to resistance of embryonic stem cells to death following the withdrawal of growth factors indicating that it is involved in apoptosis.
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CHM 1是活性的抗肿瘤活性，诱导凋亡。
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CFM 4是CARP-1 mimetic， 诱导肿瘤细胞凋亡和增值。
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2，3-DCPE hydrochloride是选择性诱导肿瘤细胞凋亡。
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PRIMA-1是Restores mutant p53 activity， induces apoptosis。
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Piperlongumine，存在于胡椒科植物荜茇中的一种天然生物碱，能够增加reactive oxygen species (ROS)水平，并选择性杀死癌细胞。
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