Microtubule/Tubulin
Microtubules (micro- + tube + -ule) are a component of the cytoskeleton, found throughout the cytoplasm. They are found in eukaryotic cells, as well as some bacteria, and are formed by the polymerization of a dimer of two globular proteins, alpha and beta tubulin.
Microtubules are very important in a number of cellular processes. They are involved in maintaining the structure of the cell and, together with microfilaments and intermediate filaments, they form the cytoskeleton. They also make up the internal structure of cilia and flagella.They provide platforms for intracellular transport and are involved in a variety of cellular processes, including the movement of secretory vesicles, organelles, and intracellular macromolecular assemblies. They are also involved in chromosome separation, and are the major constituents of mitotic spindles, which are used to pull apart eukaryotic chromosomes.
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Docetaxel三水合物是紫杉醇类似物，能抑制微管解聚。
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Cabazitaxel(XRP6258; RPR-116258A)是天然的taxoid 10-deacetylbaccatin III半合成衍生物，具有抗肿瘤活性。
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Albendazole属于苯并咪唑类化合物，可抗蠕虫感染。
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Triclabendazole(CGA89317)为苯并咪唑，与微管蛋白结合，损害细胞内运输机制，且干扰蛋白质的合成。
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Epothilone A是一种类似紫杉醇的microtubule（微管）稳定剂，EC0.01为2 μM。
More
-
Docetaxel三水合物是紫杉醇类似物，能抑制微管解聚。
More
-
Cabazitaxel(XRP6258; RPR-116258A)是天然的taxoid 10-deacetylbaccatin III半合成衍生物，具有抗肿瘤活性。
More
-
Albendazole属于苯并咪唑类化合物，可抗蠕虫感染。
More
-
Triclabendazole(CGA89317)为苯并咪唑，与微管蛋白结合，损害细胞内运输机制，且干扰蛋白质的合成。
More
-
Epothilone A是一种类似紫杉醇的microtubule（微管）稳定剂，EC0.01为2 μM。
More
