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STAT


Members of the signal transducer and activator of transcription (STAT) protein family are intracellular transcription factors that mediate many aspects of cellular immunity, proliferation, apoptosis and differentiation. They are primarily activated by membrane receptor-associated Janus kinases (JAK). Dysregulation of this pathway is frequently observed in primary tumors and leads to increased angiogenesis, enhanced survival of tumors and immunosuppression. Gene knockout studies have provided evidence that STAT proteins are involved in the development and function of the immune system and play a role in maintaining immune tolerance and tumor surveillance.

  • S3I-201 EY0638

    S3I-201是一种STAT3选择性抑制剂，能够抑制STAT3-DNA结合活性，IC50为20 μM，对STAT1和STAT5抑制作用弱。

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  • SH-4-54 EY0512

    SH-4-54是一种有效的，未磷酸化的STAT3抑制剂， 结合STAT3蛋白（KD=300 nM）。

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  • Cryptotanshinone EY0355

    Cryptotanshinone是一种STAT3抑制剂，抑制STAT3 Tyr705磷酸化，对STAT3 Ser727作用效果弱，对STAT1和STAT5没有作用效果。

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  • Niclosamide EY0323

    Niclosamide, an FDA approved anthelmintic drug, is an inhibitor of Wnt co-receptor LRP6 and suppresses both the Wnt/β-catenin pathways and the mTOR/STAT3 pathway. Niclosamide抑制DNA复制，抑制STAT，IC50为0.7 μM。

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  • Fludarabine EY0005

    Fludarabine, a purine analog, is used in the treatment of hematological malignancies for the inhibition of STAT-1 activation and DNA synthesis. Fludarabine是一种STAT1活性抑制剂和DNA合成抑制剂。

    More

  • S3I-201 EY0638

    S3I-201是一种STAT3选择性抑制剂，能够抑制STAT3-DNA结合活性，IC50为20 μM，对STAT1和STAT5抑制作用弱。

    More

  • SH-4-54 EY0512

    SH-4-54是一种有效的，未磷酸化的STAT3抑制剂， 结合STAT3蛋白（KD=300 nM）。

    More

  • Cryptotanshinone EY0355

    Cryptotanshinone是一种STAT3抑制剂，抑制STAT3 Tyr705磷酸化，对STAT3 Ser727作用效果弱，对STAT1和STAT5没有作用效果。

    More

  • Niclosamide EY0323

    Niclosamide, an FDA approved anthelmintic drug, is an inhibitor of Wnt co-receptor LRP6 and suppresses both the Wnt/β-catenin pathways and the mTOR/STAT3 pathway. Niclosamide抑制DNA复制，抑制STAT，IC50为0.7 μM。

    More

  • Fludarabine EY0005

    Fludarabine, a purine analog, is used in the treatment of hematological malignancies for the inhibition of STAT-1 activation and DNA synthesis. Fludarabine是一种STAT1活性抑制剂和DNA合成抑制剂。

    More
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