NMDAR
NMDAR(N-methyl-D-aspartate receptor) is a glutamate receptor and ion channel protein found in nerve cells. It is activated when glutamate and glycine (or D-serine) bind to it, and when activated it allows positively charged ions to flow through the cell membrane. The NMDA receptor is very important for controlling synaptic plasticity and memory function. The NMDAR is a specific type of ionotropic glutamate receptor.
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Ifenprodil就是酸盐是NMDA受体拮抗剂,选择性抑制含NR2B亚基受体。
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Latrepirdine是一种抗组织胺的药物。
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Huperzine A是传统中草药中提取的活性石松属生物碱,是可逆的乙酰胆碱酯酶(ACE)抑制剂,在中国被广泛的运用于阿尔茨海默病。
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NMDA(N-Methyl-D-aspartic acid)是氨基酸衍生物,是NMDA受体特异性激动剂,能模拟谷氨酸作用于该受体的效应。
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(-)-MK 801马来酸盐是(+)-MK-801的对映体,(+)-MK-801是高效选择性NMDA受体拮抗剂。
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