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Signal Pathway


In some cases, receptor activation caused by ligand binding to a receptor is directly coupled to the cell's response to the ligand. For example, the neurotransmitter GABA can activate a cell surface receptor that is part of an ion channel. GABA binding to a GABAA receptor on a neuron opens a chloride-selective ion channel that is part of the receptor. GABAA receptor activation allows negatively charged chloride ions to move into the neuron, which inhibits the ability of the neuron to produce action potentials.

  • U0126 EY8002

    U0126 是一种有效，非 ATP 竞争性的，选择性的 MEK1 和 MEK2 抑制剂，IC50 分别为 72 nM 和 58 nM。U0126 是一种自噬 (autophagy) 和线粒体自噬 (mitophagy) 抑制剂.

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  • Pyridone 6 吡啶酮6 EY8101

    Pyridone 6是一种泛JAK抑制剂,对JAK2, TYK2, JAK3和JAK1的IC50分别为1nM,1nM,5 nM和15 nM

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  • Magnesium sulfate EY3036

    Magnesium sulfate 是一种钙拮抗剂和有效的 L 型钙通道抑制剂，也是一种宫缩抑制剂。Magnesium sulfate 具有抗炎、抗惊厥、血管舒张和神经保护的作用。Magnesium sulfate 可用于先兆子痫/子痫等疾病的研究

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  • PtdIns (4)-P1-fluorescein (ammonium salt) MA2536

    PtdIns (4)-P1-fluorescein (ammonium salt) is a fluorescent derivative of phosphatidylinositol

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  • Clozapine N-oxide EY3996

    Clozapine N-oxide is a major metabolite of Clozapine and a human muscarinic designer receptors (DREADDs) agonist. Clozapine N-oxide activates the DREADD receptor hM3Dq and hM4Di.

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