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Signal Pathway


In some cases, receptor activation caused by ligand binding to a receptor is directly coupled to the cell's response to the ligand. For example, the neurotransmitter GABA can activate a cell surface receptor that is part of an ion channel. GABA binding to a GABAA receptor on a neuron opens a chloride-selective ion channel that is part of the receptor. GABAA receptor activation allows negatively charged chloride ions to move into the neuron, which inhibits the ability of the neuron to produce action potentials.

  • GW 542573X EI1262

    GW 542573X是KCa2.1 离子通道选择性激动剂。

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  • GW 583340 dihydrochloride EI1263

    GW 583340 dihydrochloride是活性的双效EGFR/ErbB2抑制剂， 口服有效。

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  • GW 7647 EI1266

    GW 7647是高选择性活性的 PPARα 激动剂。 口服有效。

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  • GW 791343 hydrochloride EI1267

    GW 791343 hydrochloride是P2X7 变构的调节剂 (allosteric modulator)。

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  • GW 6471 EI1265

    GW 6471 is a potent antagonist of PPARα with IC50 of 0.24 μM.

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