Home > 暂无记录 暂无记录 Signal Pathway

Signal Pathway


In some cases, receptor activation caused by ligand binding to a receptor is directly coupled to the cell's response to the ligand. For example, the neurotransmitter GABA can activate a cell surface receptor that is part of an ion channel. GABA binding to a GABAA receptor on a neuron opens a chloride-selective ion channel that is part of the receptor. GABAA receptor activation allows negatively charged chloride ions to move into the neuron, which inhibits the ability of the neuron to produce action potentials.

  • Navlimetostat EY8033

    MRTX1719 is a potent and selective inhibitor of the protein arginine methyltransferase 5·methylthioadenosine phosphorylase complex (PRMT5·MTA), which serves as a potential selective therapeutic target for tumor intervention.

    More

  • Onametostat EY8032

    Onametostat (JNJ-64619178)是PRMT5抑制剂，具有较高的选择性和效力（PRMT5-MEP-50, IC50=0.14 nM）、良好的药代动力学特性以及安全性

    More

  • Copanlisib EY8031

    Copanlisib是一个高效的泛I型 PI3K抑制剂，其对PI3Kα/β/γ/δ抑制的IC50分别为0.5, 3.7, 6.4, and 0.7 nM。Phase 3.

    More

  • Zimlovisertib EY8028

    Zimlovisertib (PF-06650833)是一种有效的IRAK4选择性抑制剂，IC50为0.2 nM

    More

  • Edecesertib EY8026

    Edecesertib (GS-5718) 是一种具有选择性且口服有效的 IRAK-4 抑制剂。Edecessertib 具有抗炎活性。Edecessertib 可用于类风湿性关节炎 (RA) 和红斑狼疮 (LE) 的研究.

    More
    • Current page2, Total Pages360, Total Record1796 First Prev 12345 Next Last Goto
More