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Signal Pathway


In some cases, receptor activation caused by ligand binding to a receptor is directly coupled to the cell's response to the ligand. For example, the neurotransmitter GABA can activate a cell surface receptor that is part of an ion channel. GABA binding to a GABAA receptor on a neuron opens a chloride-selective ion channel that is part of the receptor. GABAA receptor activation allows negatively charged chloride ions to move into the neuron, which inhibits the ability of the neuron to produce action potentials.

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    Fenspiride is a bronchodilator with anti-inflammatory properties, inhibiting phosphodiesterase 4 and phosphodiesterase 3 activities with logIC50 values of 4.16 and 3.44, respectively, in human isolated bronchi.

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  • Brompheniramine hydrogen maleate EY2861

    Brompheniramine hydrogen maleate is a histamine H1 receptors antagonist.

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  • Sulbactam sodium EY2851

    Sulbactam sodium (Unasyn) is an irreversible β-lactamase inhibitor.

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  • Azelastine HCl EY2852

    Azelastine hydrochloride (Astelin) is a potent, second-generation, selective, histamine antagonist.

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  • Cortisone acetate EY2854

    Cortisone acetate (Cortone) is an acetate salt form of cortisone that is a steroid hormone and a glucocorticoid.

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