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Hedgehog


The Hedgehog signaling pathway is a signaling pathway that transmits information to embryonic cells required for proper cell differentiation. Different parts of the embryo have different concentrations of hedgehog signaling proteins. The pathway also has roles in the adult. Diseases associated with the malfunction of this pathway include basal cell carcinoma.

  • Vismodegib EY0025

    Vismodegib (GDC-0449)是一种有效的，新型的，特异性的hedgehog抑制剂，IC50为3 nM。GDC-0449也抑制P-gp作用，IC50为3.0μM。

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  • Taladegib EY1618

    LY2940680能结合Smoothened (Smo)受体，并抑制Hedgehog (Hh)信号传导。

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  • Glasdegib EY1249

    PF-04449913是口服生物相容性的smoothened抑制剂，IC50为5 nM，是hedgehog通路抑制剂。

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  • SANT-1 EY0774

    SANT-1直接结合到Smoothened (Smo)受体，Kd为1.2 nM，且抑制smo激动剂作用效果，IC50为20 nM。

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