VDAC
VDAC (Voltage-dependent anion channels) are a class of porin ion channel located on the outer mitochondrial membrane. VDAC facilitates the exchange of ions and molecules between mitochondria and cytosol and is regulated by the interactions with other proteins and small molecules. The voltage-dependent ion channel plays a key role in regulating metabolic and energetic flux across the outer mitochondrial membrane.
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Sulfapyridine is an antibiotic and is mostly used in treating rheumatoid arthritis.
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Sulfameter(Bayrena) is a long-acting sulfonamide antibacterial.
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Alendronate is an inhibitor of CD45RC and MMP. It is also a selective inhibitor of FDPS (farnesyl diphosphate synthase). Alendronate, a nitrogen-containing bisphosphonate, is a potent inhibitor of bone resorption used for the treatment and prevention of osteoporosis.
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Chlorothiazide is one of the first in the thiazide class of diuretics. It is an inhibitor of carbonic anhydrase (IC50=3.8 mM) and is slightly less potent than acetazolamide (sc-214461). This compound has been shown to block reabsorption of sodium and chloride ions.
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Ursodiol reduces cholesterol absorption and is used to dissolve (cholesterol) gallstones. (IC50=0.22 μM). Ursodiol is a bile acid with significant colon chemopreventive activity.
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