Sodium Channel
Sodium channels are integral membrane proteins that form ion channels, conducting sodium ions (Na+) through a cell's plasma membrane. They are classified according to the trigger that opens the channel for such ions, i.e. either a voltage-change ("Voltage-gated", "voltage-sensitive", or "voltage-dependent" sodium channel also called "VGSCs" or "Nav channel") or a binding of a substance (a ligand) to the channel (ligand-gated sodium channels). In excitable cells such as neurons, myocytes, and certain types of glia, sodium channels are responsible for the rising phase of action potentials.
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JNJ 10181457 dihydrochloride是H3 拮抗剂。
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JNJ 10191584 maleate是选择性 H4 受体 拮抗剂， 口服有效。
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Iodophenpropit dihydrobromide是活性选择性H3拮抗剂。
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Impentamine dihydrobromide是选择性 H3 拮抗剂。
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Imetit dihydrobromide是标准H3和H4 激动剂 (H3 > H4)。
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