Sodium Channel
Sodium channels are integral membrane proteins that form ion channels, conducting sodium ions (Na+) through a cell's plasma membrane. They are classified according to the trigger that opens the channel for such ions, i.e. either a voltage-change ("Voltage-gated", "voltage-sensitive", or "voltage-dependent" sodium channel also called "VGSCs" or "Nav channel") or a binding of a substance (a ligand) to the channel (ligand-gated sodium channels). In excitable cells such as neurons, myocytes, and certain types of glia, sodium channels are responsible for the rising phase of action potentials.
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TC-N 1752是选择性 NaV1.7 通道阻断剂。
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Sipatrigine是NaV 通道阻断剂， 具有神经保护活性。
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SEN 12333是α7 nAChR的激动剂也是 histamine H3的拮抗剂。
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ROS 234 dioxalate是活性的 H3 拮抗剂。
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Ralfinamide mesylate是Na+ 通道阻断剂。
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