Proton Pump
The proton pump is an integral membrane protein that is capable of moving protons across a biological membrane. Mechanisms are based on conformational changes of the protein structure or on the Q cycle. In cell respiration, the proton pump uses energy to transport protons from the matrix of the mitochondrion to the inter-membrane space. The proton pump does not create energy, but forms a gradient that stores energy for later use.
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Imatinib Mesylate (STI571)是Imatinib的甲磺酸盐，具有较好的口服生物利用度，是一种多靶点的抑制剂，同时作用于v-Abl， c-Kit和PDGFR，IC50分别为0.6 μM， 0.1 μM 和0.1 μM。
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Imatinib (STI571)是一种多靶点酪氨酸激酶抑制剂，作用于v- v-Abl， c-Kit和PDGFR 时，IC50分别为0.6， 0.1和0.1 μM。
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Dasatinib是一种Src/Abl抑制剂，IC50分别为0.6 nM和0.8 nM。
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Lonafarnib(Sch66336)是口服生物相容性的FPTase抑制剂，对H-ras，K-ras-4B和N-ras的IC50分别为1.9 nM，5.2 nM和2.8 nM。
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BX795是TBK1和PDK1双重抑制剂，IC50分别为2 nM和6 nM，比对PKA，PKC，c-Kit和GSK3β的抑制性高50倍。
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