P-gp
P-gp (permeability glycoprotein) is an important protein of the cell membrane that pumps many foreign substances out of cells. It is an ATP-dependent efflux pump with broad substrate specificity. It exists in animals, fungi and bacteria and likely evolved as a defense mechanism against harmful substances. P-gp is a glycoprotein that in humans is encoded by the ABCB1 gene. P-gp is a well-characterized ABC-transporter (which transports a wide variety of substrates across extra- and intracellular membranes) of the MDR/TAP subfamily.
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K02288是一种高度选择性I型BMP受体抑制剂，针对 ALK2， ALK1和ALK6的IC50分别为1.1，1.8，6.4 nm，显示对其他ALKS（3，4，5）和的ActRIIa 有轻微抑制作用。
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AZD-3463是ALK/IGF1R抑制剂。
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GSK1838705A是IGF-IR，InsR和ALK抑制剂，IC50分别为2.0，1.6和0.5 nM。
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Megestrol Acetate能抑制HegG2，IC50为260 μM。
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(R)-baclofen是一种γ-氨基丁酸衍生物，主要用于治疗痉挛。是选择性GABAB受体激动剂。
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K02288是一种高度选择性I型BMP受体抑制剂，针对 ALK2， ALK1和ALK6的IC50分别为1.1，1.8，6.4 nm，显示对其他ALKS（3，4，5）和的ActRIIa 有轻微抑制作用。
More
-
AZD-3463是ALK/IGF1R抑制剂。
More
-
GSK1838705A是IGF-IR，InsR和ALK抑制剂，IC50分别为2.0，1.6和0.5 nM。
More
-
Megestrol Acetate能抑制HegG2，IC50为260 μM。
More
-
(R)-baclofen是一种γ-氨基丁酸衍生物，主要用于治疗痉挛。是选择性GABAB受体激动剂。
More
