BI-D1870是ATP竞争性S6核糖体抑制剂,对RSK1/2/3/4的IC50分别为31 nM/24 nM/18 nM/15 nM,比对MST2,GSK-3β,MARK3,CK1 和Aurora B的抑制性高10到100倍。
MoreDoxorubicin (Adriamycin)是一种抗生素类试剂,能够抑制DNA拓扑异构酶II,且诱导DNA损伤和凋亡。
MoreSorafenib (BAY 43-9006), an orally active multi-kinase inhibitor, targets RAF/MEK/ERK pathway in tumor cells and tyrosine kinases VEGFR/PDGFR in tumor vasculature. Sorafenib是Raf-1, B-Raf和VEGFR-2等的多重激酶抑制剂,IC50分别为6 nM, 22 nM和90 nM。
MoreNatural triterpenoid that displays anti-HIV and antitumor activity. Induces the production of reactive oxygen species (ROS) and activates NF-κB. Exhibits GPBA receptor agonist activity (EC50 = 1.04 μM).
More(S)-10-Hydroxycamptothecin 是临床治疗肝癌的有效试剂。
MoreBI-D1870是ATP竞争性S6核糖体抑制剂,对RSK1/2/3/4的IC50分别为31 nM/24 nM/18 nM/15 nM,比对MST2,GSK-3β,MARK3,CK1 和Aurora B的抑制性高10到100倍。
MoreDoxorubicin (Adriamycin)是一种抗生素类试剂,能够抑制DNA拓扑异构酶II,且诱导DNA损伤和凋亡。
MoreSorafenib (BAY 43-9006), an orally active multi-kinase inhibitor, targets RAF/MEK/ERK pathway in tumor cells and tyrosine kinases VEGFR/PDGFR in tumor vasculature. Sorafenib是Raf-1, B-Raf和VEGFR-2等的多重激酶抑制剂,IC50分别为6 nM, 22 nM和90 nM。
MoreNatural triterpenoid that displays anti-HIV and antitumor activity. Induces the production of reactive oxygen species (ROS) and activates NF-κB. Exhibits GPBA receptor agonist activity (EC50 = 1.04 μM).
More(S)-10-Hydroxycamptothecin 是临床治疗肝癌的有效试剂。
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