P2X receptor


The ATP-gated P2X Receptor Cation Channel (P2X Receptor) Family consists of cation-permeable ligand gated ion channels that open in response to the binding of extracellular adenosine 5'-triphosphate (ATP). They belong to a larger family of receptors known as the ENaC/P2X superfamily. ENaC and P2X receptors have similar 3-D structures and are homologous.
  • BI-D1870 EY0449

    BI-D1870是ATP竞争性S6核糖体抑制剂,对RSK1/2/3/4的IC50分别为31 nM/24 nM/18 nM/15 nM,比对MST2,GSK-3β,MARK3,CK1 和Aurora B的抑制性高10到100倍。

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  • Doxorubicin EY0354

    Doxorubicin (Adriamycin)是一种抗生素类试剂,能够抑制DNA拓扑异构酶II,且诱导DNA损伤和凋亡。

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  • Sorafenib EY0017

    Sorafenib (BAY 43-9006), an orally active multi-kinase inhibitor, targets RAF/MEK/ERK pathway in tumor cells and tyrosine kinases VEGFR/PDGFR in tumor vasculature. Sorafenib是Raf-1, B-Raf和VEGFR-2等的多重激酶抑制剂,IC50分别为6 nM, 22 nM和90 nM。

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  • Betulinic acid EY1794

    Natural triterpenoid that displays anti-HIV and antitumor activity. Induces the production of reactive oxygen species (ROS) and activates NF-κB. Exhibits GPBA receptor agonist activity (EC50 = 1.04 μM).

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  • (S)-10-Hydroxycamptothecin EY1614

    (S)-10-Hydroxycamptothecin 是临床治疗肝癌的有效试剂。

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  • BI-D1870 EY0449

    BI-D1870是ATP竞争性S6核糖体抑制剂,对RSK1/2/3/4的IC50分别为31 nM/24 nM/18 nM/15 nM,比对MST2,GSK-3β,MARK3,CK1 和Aurora B的抑制性高10到100倍。

    More
  • Doxorubicin EY0354

    Doxorubicin (Adriamycin)是一种抗生素类试剂,能够抑制DNA拓扑异构酶II,且诱导DNA损伤和凋亡。

    More
  • Sorafenib EY0017

    Sorafenib (BAY 43-9006), an orally active multi-kinase inhibitor, targets RAF/MEK/ERK pathway in tumor cells and tyrosine kinases VEGFR/PDGFR in tumor vasculature. Sorafenib是Raf-1, B-Raf和VEGFR-2等的多重激酶抑制剂,IC50分别为6 nM, 22 nM和90 nM。

    More
  • Betulinic acid EY1794

    Natural triterpenoid that displays anti-HIV and antitumor activity. Induces the production of reactive oxygen species (ROS) and activates NF-κB. Exhibits GPBA receptor agonist activity (EC50 = 1.04 μM).

    More
  • (S)-10-Hydroxycamptothecin EY1614

    (S)-10-Hydroxycamptothecin 是临床治疗肝癌的有效试剂。

    More
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