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GlyT1


Elevation of extracellular synaptic glycine concentration by blockade of GlyT1 has been hypothesized to potentiate NMDA receptor function in vivo and to represent a rational approach for the treatment of schizophrenia and cognitive disorders.

  • SB225002 EY0819

    SB225002是趋化因子受体CXCR2高校选择性抑制剂，IC50值为22nM，对CXCR1及其他7-TMRs跨膜受体抑制力弱或无。

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  • Plerixafor EY0683

    Plerixafor (AMD3100)是一种CXCR4趋化因子受体拮抗剂，抑制CXCR4和CXCL12调节的趋化性，IC50分别为44 nM和5.7 nM。

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  • TH588 EY0584

    TH588是MTH1(NUDT1)高效选择性抑制剂，IC50值5nM。

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  • Plerixafor 8HCl EY0548

    Plerixafor八盐酸盐是CXCR4趋化因子受体拮抗剂，能够拮抗CXCR4和CXCL12调节的趋化作用， IC50分别为44 nM和5.7 nM。

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  • WZ811 EY1768

    WZ811是一种高效的，竞争性的CXCR4拮抗剂，EC50为0.3 nM。

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