Gardos Channel
Gardos Channel (Potassium intermediate/small conductance calcium-activated channel, subfamily N,KCNN4) is a human gene encoding the KCa3.1 protein. The KCa3.1 protein is part of a potentially heterotetrameric voltage-independent potassium channel that is activated by intracellular calcium. Activation is followed by membrane hyperpolarization, which promotes calcium influx. The encoded protein may be part of the predominant calcium-activated potassium channel in T-lymphocytes. This gene is similar to other KCNN family potassium channel genes, but it differs enough to possibly be considered as part of a new subfamily.
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Sirtinol是一种特异性SIRT1和SIRT2抑制剂，IC50分别为131 μM和38 μM。
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Tubastatin A盐酸盐是HDAC6选择性抑制剂，IC50为15 nM，比对其它亚型的抑制性高1000倍（相对HDAC8是57倍）。
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Sodium phenylbutyrate (NaPB), a derivative of the short-chain fatty acid butyrate, is a low-potency histone deacetylase inhibitor and originally approved for treatment of UCD. Sodium Phenylbutyrate是一种转录调节因子，通过调控HDAC活性来改变染色质结构从而发挥作用,是组蛋白脱乙酰酶（HDAC）抑制剂，IC50为1-5 uM。
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Entinostat (MS-27-275, MS-275, SNDX-275) an orally class I histone deacetylase (HDAC)-specific inhibitor, is currently in clinical trials.
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Ricolinostat (ACY-1215) is an oral, first-in-class, selective inhibitor of HDAC6, and inhibits tubulin deacetylase. Rocilinostat (ACY-1215)是高效HDAC6抑制剂，IC50为5 nM，比对HDAC1/2/3的抑制性高10倍以上，对HDAC8有微弱活性，对HDAC4/5/7/9/11，Sirtuin1和Sirtuin2活性最低。
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