Gardos Channel
Gardos Channel (Potassium intermediate/small conductance calcium-activated channel, subfamily N,KCNN4) is a human gene encoding the KCa3.1 protein. The KCa3.1 protein is part of a potentially heterotetrameric voltage-independent potassium channel that is activated by intracellular calcium. Activation is followed by membrane hyperpolarization, which promotes calcium influx. The encoded protein may be part of the predominant calcium-activated potassium channel in T-lymphocytes. This gene is similar to other KCNN family potassium channel genes, but it differs enough to possibly be considered as part of a new subfamily.
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Belinostat是一种新型的HDAC抑制剂，IC50为27 nM，对抵抗Cisplatin的肿瘤有效。
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Quisinostat (JNJ-26481585)是一种新型的，二代HDAC抑制剂，对HDAC作用最有效，IC50为0.11 nM，适度有效作用于HDACs 2， 4， 10，和11；比作用于HDACs 3， 5， 8，和9选择性强30倍，对HDACs 6和7作用效果最弱。
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CI-994 (Tacedinaline)是抗癌化合物，能抑制HDAC1，IC50为0.57 μM，能促使细胞周期停滞于G1期。
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Trichostatin A (TSA)是一种HDAC抑制剂，IC50为1.8 nM左右，HDAC8是HDAC家族中唯一不受TSA影响的成员。
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Tubacin是一种选择性的，可逆的，细胞通透性的HDAC6抑制剂，IC50为4 nM。
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