EAATs(Glutamate transporters)
EAATs (Glutamate transporters, Excitatory amino-acid transporters,SLC1, GLT-1), being the most abundant subtype of glutamate transporter in the CNS, is a protein thatplays a key role in regulation of glutamate neurotransmission. and are sodium- and potassium-dependent members of the solute carrier family 6 (SLC1) found widely distributed throughout the brain. There are five EAAT subtypes, each with a specific primary distribution; EAAT1 (cerebellar glia), EAAT2 (forebrain glia), EAAT3 (cortical neurons), EAAT4 (cerebellar Purkinje neurons) and EAAT5 (retina).
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NBI 35965 hydrochloride是活性的，选择性 CRF1 拮抗剂。
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L-trans-2，4-PDC是Transportable EAAT1-4 抑制剂/non-transportable EAAT5 抑制剂。
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LDN 212320是LDN 212320 increases EAAT2 expression， neuroprotective activity。
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L-(-)-threo-3-Hydroxyaspartic acid是Transportable EAAT1-4 抑制剂也是非transportable EAAT5 抑制剂。
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Cisplatin是一种无机的水溶性的铂配合物，通过形成DNA交联剂而抑制DNA合成。
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