EAATs(Glutamate transporters)
EAATs (Glutamate transporters, Excitatory amino-acid transporters,SLC1, GLT-1), being the most abundant subtype of glutamate transporter in the CNS, is a protein thatplays a key role in regulation of glutamate neurotransmission. and are sodium- and potassium-dependent members of the solute carrier family 6 (SLC1) found widely distributed throughout the brain. There are five EAAT subtypes, each with a specific primary distribution; EAAT1 (cerebellar glia), EAAT2 (forebrain glia), EAAT3 (cortical neurons), EAAT4 (cerebellar Purkinje neurons) and EAAT5 (retina).
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L-(-)-threo-3-Hydroxyaspartic acid是Transportable EAAT1-4 抑制剂也是非transportable EAAT5 抑制剂。
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Cisplatin是一种无机的水溶性的铂配合物，通过形成DNA交联剂而抑制DNA合成。
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SCR7 is a specific DNA Ligase IV inhibitor (IC50 = 40 nM in Hela and A549 cell).
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Gemcitabine HCl是一种DNA合成抑制剂，作用于PANC1， MIAPaCa2， BxPC3和Capan2细胞时，IC50分别为50 nM， 40 nM， 18 nM和12 nM。
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Oxaliplatin通过与DNA交联而抑制DNA合成。
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