EAATs(Glutamate transporters)
EAATs (Glutamate transporters, Excitatory amino-acid transporters,SLC1, GLT-1), being the most abundant subtype of glutamate transporter in the CNS, is a protein thatplays a key role in regulation of glutamate neurotransmission. and are sodium- and potassium-dependent members of the solute carrier family 6 (SLC1) found widely distributed throughout the brain. There are five EAAT subtypes, each with a specific primary distribution; EAAT1 (cerebellar glia), EAAT2 (forebrain glia), EAAT3 (cortical neurons), EAAT4 (cerebellar Purkinje neurons) and EAAT5 (retina).
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Antalarmin hydrochloride是CRF1 拮抗剂。
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(±)-threo-3-Methylglutamic acid是EAAT2，EAAT4 blocker (EAAT2，EAAT4阻断剂)。
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(±)-HIP-A是活性的， 非竞争性 EAAT 抑制剂。
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WAY 213613是WAY 213613 is a potent, non-substrate EAAT2 inhibitor.。
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UCPH 101是UCPH 101 is a selective non-substrate EAAT1 inhibitor.。
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