EAATs(Glutamate transporters)
EAATs (Glutamate transporters, Excitatory amino-acid transporters,SLC1, GLT-1), being the most abundant subtype of glutamate transporter in the CNS, is a protein thatplays a key role in regulation of glutamate neurotransmission. and are sodium- and potassium-dependent members of the solute carrier family 6 (SLC1) found widely distributed throughout the brain. There are five EAAT subtypes, each with a specific primary distribution; EAAT1 (cerebellar glia), EAAT2 (forebrain glia), EAAT3 (cortical neurons), EAAT4 (cerebellar Purkinje neurons) and EAAT5 (retina).
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FT-207 (NSC 148958) is a substance being used in the treatment of some types of cancer.
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Clofarabine is a potent HIV-1 inhibitor in both activated CD4+ T cells and macrophages. Clofarabine inhibits the enzymatic activities of ribonucleotide reductase (IC50 = 65 nM) and DNA polymerase
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DL-TBOA是选择性 non-transportable inhibitor of EAATs 。
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Dihydrokainic acid是L-glutamate的EAAT2 (GLT-1)选择性非转运型抑制剂（non-transportable inhibitor）并且是L-aspartate uptake inhibitor（摄取抑制剂）。
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CP 376395 hydrochloride是活性选择性 CRF1 拮抗剂。
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