EAATs(Glutamate transporters)
EAATs (Glutamate transporters, Excitatory amino-acid transporters,SLC1, GLT-1), being the most abundant subtype of glutamate transporter in the CNS, is a protein thatplays a key role in regulation of glutamate neurotransmission. and are sodium- and potassium-dependent members of the solute carrier family 6 (SLC1) found widely distributed throughout the brain. There are five EAAT subtypes, each with a specific primary distribution; EAAT1 (cerebellar glia), EAAT2 (forebrain glia), EAAT3 (cortical neurons), EAAT4 (cerebellar Purkinje neurons) and EAAT5 (retina).
-
Nelarabine是嘌呤核苷酸类似物，为DNA合成抑制剂，对肿瘤细胞的IC50为0.067-2.15 μM，可作用于T细胞急性淋巴细胞白血病。
More
-
Cyclocytidine HCl 是Cytarabine的前体药物，是一种嘧啶核苷类似物，抑制DNA synthesis，主要用于治疗白血病。
More
-
Mercaptopurine是免疫抑制剂。
More
-
Bendamustine hydrochloride是DNA损伤剂，IC50为50 μM。
More
-
Ifosfamide是DNA烷化剂。Ifosfamide is a nitrogen mustard alkylating agent used in the treatment of cancer.
More
