EAATs(Glutamate transporters)
EAATs (Glutamate transporters, Excitatory amino-acid transporters,SLC1, GLT-1), being the most abundant subtype of glutamate transporter in the CNS, is a protein thatplays a key role in regulation of glutamate neurotransmission. and are sodium- and potassium-dependent members of the solute carrier family 6 (SLC1) found widely distributed throughout the brain. There are five EAAT subtypes, each with a specific primary distribution; EAAT1 (cerebellar glia), EAAT2 (forebrain glia), EAAT3 (cortical neurons), EAAT4 (cerebellar Purkinje neurons) and EAAT5 (retina).
-
Cladribine (克拉屈滨) 是腺苷脱氨酶(adenosine deaminase)抑制剂,可作用于毛细胞白血病和多发性硬化。
More
-
Mizoribine 是一种咪唑核苷,是一种免疫抑制剂,IC50约为100μM。
More
-
Metronidazole是硝基咪唑类抗生素,对厌氧菌和原生动物较有效。
More
-
BMH-21是一新型DNA嵌入剂(DNA intercalator),能结合rDNA并抑制RNA polymerase I的转录,不使组蛋白H2AX磷酸化。
More
-
Cidofovir可通过抑制病毒DNA聚合酶活性以控制巨细胞病毒CMV复制。
More