EAATs(Glutamate transporters)
EAATs (Glutamate transporters, Excitatory amino-acid transporters,SLC1, GLT-1), being the most abundant subtype of glutamate transporter in the CNS, is a protein thatplays a key role in regulation of glutamate neurotransmission. and are sodium- and potassium-dependent members of the solute carrier family 6 (SLC1) found widely distributed throughout the brain. There are five EAAT subtypes, each with a specific primary distribution; EAAT1 (cerebellar glia), EAAT2 (forebrain glia), EAAT3 (cortical neurons), EAAT4 (cerebellar Purkinje neurons) and EAAT5 (retina).
-
Trifluridine (Viroptic)是一种抗疱疹病毒药，主要用于眼部。是胸苷磷酸化酶（thymidine phosphorylase）抑制剂，还能抑制胸苷酸合成酶（thymidylate synthase）。
More
-
Dacarbazine是一种抗肿瘤化疗药物，用于治疗多种癌症。
More
-
Daphnetin是天然香豆素衍生物，是一种蛋白激酶抑制剂，抑制EGFR， PKA和PKC，IC50分别为7.67 μM， 9.33 μM和25.01 μM，且具有抗炎和抗氧化剂活动性。
More
-
Fidaxomicin是选择性的梭状芽孢杆菌抗生素。
More
-
Pyridostatin能通过诱导复制和转录依赖的DNA损伤促使人癌细胞生长停滞。
More
