CFTR
CFTR (Cystic fibrosis transmembrane conductance regulator) is a membrane protein and chloride channel in vertebrates that is encoded by the CFTR gene. The CFTR gene codes for an ABC transporter-class ion channel protein that conducts chloride and thiocyanate ions across epithelial cell membranes. Mutations of the CFTR gene affecting chloride ion channel function lead to dysregulation of epithelial fluid transport in the lung, pancreas and other organs, resulting in cystic fibrosis.
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AZ20是高活性ATR抑制剂，IC50为5 nM，对mTOR的IC50为38 nM。
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Edoxaban是factor Xa选择性抑制剂，也是具有口服效应的抗凝药物。
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MK-3207 HCl是一种有效的CGRP受体拮抗剂，IC50和Ki分别为0.12 nM和0.022 nM，对人AM1， AM2， CTR，和AMY3具有高度选择性。
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CGK 733是一种有效的ATM/ATR选择性抑制剂，IC50约为200 nM。
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CFTR(inh)-172是快速可逆的CFTR抑制剂，Ki为300 nM，常用于囊胞性纤维症和分泌性腹泻等动物模型。
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