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Nisoldipine (Sular) is a calcium channel blocker belonging to the dihydropyridines class, specific for L-type Cav1.2 with IC50 of 10 nM.
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Isradipine is a 2,4-dihydropyridine selective agonist and calcium channel protein inhibitor( IC50 = 34±8 μM). Research has indicated that Isradipine has anti-atherosclerotic effects in animals and improves endothelium-mediated nitric oxide (NO)-dependent vasodilation in vitro. Additional studies indicate that Isradipine may provide a neuroprotective effect in a rat model of focal ischemia and that Isradipine produces a dose-dependent sparing of dopamine neuronal fibers and cell bodies.
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Ibutilide hemifumarate是Ibutilide hemifumarate blocks Ikr, hERG, L-type Ca2+ channels, class III antiarrhythmic。
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FPL 64176是Ca2+ 离子通道的活性激动剂 (L-type)。
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Flunarizine dihydrochloride是双效 Na+/Ca2+ 离子通道阻断剂 (T-type)。
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