p97


p97 knows also as VCP ( Cdc48 in yeast) is a hexameric ATPase of the AAA family which disassembles SNARE proteins after membrane fusion. It is involved in a fusion of homotypic membranes, protein degradation, and activation of membrane-bound transcription factors.
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    Mycophenolic acid是一种免疫抑制剂,用于预防器官移植排斥。

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  • AGI-5198 EY0561

    AGI-5198是第一个高效的,是剂量依赖的R132H-IDH1抑制剂选择性的IDH1 R132H/R132C突变型抑制剂,IC50为0.07 μM/0.16 μM。

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  • Calcitriol EY0364

    Calcitriol, the active form of vitamin D, is known for its anticancer properties including induction of apoptosis as well as the inhibition of angiogenesis and metastasis.Calcitriol(1,25-Dihydroxyvitamin D3; Rocaltrol )是维生素D3的活性代谢物,能激活维生素D受体(VDR)。

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  • AGI-6780 EY0372

    AGI-6780, a heterocyclic urea sulfonamide molecule, potently and selectively inhibits the tumor-associated IDH2 R140Q mutant. AGI-6780 是一种强效的选择性 IDH2 R140Q mutant抑制剂,其IC50为 23 nM。

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  • Isotretinoin EY1789

    Isotretinoin (异维A酸; 13-cis-Retinoic acid) 可作用于重度粉刺,还可用于脑癌,胰腺癌等化疗。

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