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p97


p97 knows also as VCP ( Cdc48 in yeast) is a hexameric ATPase of the AAA family which disassembles SNARE proteins after membrane fusion. It is involved in a fusion of homotypic membranes, protein degradation, and activation of membrane-bound transcription factors.

  • LY 225910 EI1585

    LY 225910是活性的 CCK2 拮抗剂。

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  • L-365，260 EI1474

    L-365，260是选择性 CCK2 拮抗剂。

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  • NMS-873 EY1529

    NMS-873是VCP/p97变构抑制剂，IC50为20 nM。

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  • DBeQ EY1406

    DBeQ是一种选择性的，有效的，可逆的，ATP竞争性的p97抑制剂，IC50为1.5 μM。

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  • CPI-613 EY0939

    CPI-613是Lipoate类似物，抑制线粒体酶pyruvate dehydrogenase (PDH)（丙酮酸脱氢酶）和α-ketoglutarate dehydrogenase（α-酮戊二酸脱氢酶），干扰肿瘤细胞线粒体代谢。

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