E2 enzymes
E2 enzymes (Ubiquitin-conjugating enzymes) perform the second step in the ubiquitination reaction that targets a protein for degradation via the proteasome.The ubiquitination process covalently attaches ubiquitin, a short protein of 76 amino acids, to a lysine residue on the target protein. Once a protein has been tagged with one ubiquitin molecule, additional rounds of ubiquitination form a polyubiquitin chain that is recognized by the proteasome's 19S regulatory particle, triggering the ATP-dependent unfolding of the target protein that allows passage into the proteasome's 20S core particle, where proteases degrade the target into short peptide fragments for recycling by the cell.
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SB269970盐酸盐是5-HT7受体拮抗剂，pKi为8.3，比对其它受体的抑制性高50倍以上。
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Risperidone（R64766）是5-HT2受体阻断剂和多巴胺D2受体拮抗剂，Ki值分别为0.16和1.4nM。
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Ketoconazole (酮康唑)是咪唑类抗真菌剂，是经典的CYP3A4抑制剂。
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Amitriptyline HCl 是一种三环抗抑郁药，抑制5-羟色胺受体，去甲肾上腺素受体， 5-HT4， 5-HT2和sigma 1受体。
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Blonanserin(AD-5423)是D2/5-HT2受体拮抗剂。
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