E2 enzymes
E2 enzymes (Ubiquitin-conjugating enzymes) perform the second step in the ubiquitination reaction that targets a protein for degradation via the proteasome.The ubiquitination process covalently attaches ubiquitin, a short protein of 76 amino acids, to a lysine residue on the target protein. Once a protein has been tagged with one ubiquitin molecule, additional rounds of ubiquitination form a polyubiquitin chain that is recognized by the proteasome's 19S regulatory particle, triggering the ATP-dependent unfolding of the target protein that allows passage into the proteasome's 20S core particle, where proteases degrade the target into short peptide fragments for recycling by the cell.
-
L-694，247是5-HT1D 激动剂。
More
-
Ketanserin tartrate是选择性 5-HT2A 拮抗剂。 也是5-HT1D的拮抗剂。
More
-
Isamoltane hemifumarate是5-HT1B 拮抗剂。
More
-
Ipsapirone是选择性 5-HT1A 激动剂。
More
-
Indatraline hydrochloride是活性的 5-HT uptake inhibitor（摄取抑制剂）， 也抑制 dopamine，noradrenalin的吸收。
More
