E2 enzymes
E2 enzymes (Ubiquitin-conjugating enzymes) perform the second step in the ubiquitination reaction that targets a protein for degradation via the proteasome.The ubiquitination process covalently attaches ubiquitin, a short protein of 76 amino acids, to a lysine residue on the target protein. Once a protein has been tagged with one ubiquitin molecule, additional rounds of ubiquitination form a polyubiquitin chain that is recognized by the proteasome's 19S regulatory particle, triggering the ATP-dependent unfolding of the target protein that allows passage into the proteasome's 20S core particle, where proteases degrade the target into short peptide fragments for recycling by the cell.
-
Mesulergine hydrochloride是5-HT2A 和5-HT2C 拮抗剂。 也是dopamine 受体部分激动剂。
More
-
Metergoline是5-HT2 拮抗剂。 也是5-HT1 拮抗剂，5-HT1D 配体。 对5-HT6有适度的亲核性，对5-HT7 有高亲和性 。
More
-
MDL 72832 hydrochloride是活性的5-HT1A配体。
More
-
MDL 73005EF hydrochloride是活性的，选择性 5-HT1A 部分激动剂。
More
-
Melperone hydrochloride是5-HT2A/D2 受体拮抗剂， 安定精神作用。
More
