E2 enzymes
E2 enzymes (Ubiquitin-conjugating enzymes) perform the second step in the ubiquitination reaction that targets a protein for degradation via the proteasome.The ubiquitination process covalently attaches ubiquitin, a short protein of 76 amino acids, to a lysine residue on the target protein. Once a protein has been tagged with one ubiquitin molecule, additional rounds of ubiquitination form a polyubiquitin chain that is recognized by the proteasome's 19S regulatory particle, triggering the ATP-dependent unfolding of the target protein that allows passage into the proteasome's 20S core particle, where proteases degrade the target into short peptide fragments for recycling by the cell.
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Ziprasidone hydrochloride是5-HT2A/D2 拮抗剂， atypical antipsychotic。
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Zimelidine dihydrochloride是选择性 5-HT uptake inhibitor（摄取抑制剂）。
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Xaliproden hydrochloride是口服有效， 高亲和性 5-HT1A 激动剂。
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WAY 629 hydrochloride是选择性 5-HT2C 激动剂。
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WAY 208466 dihydrochloride是选择性5-HT6激动剂。
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