Home > Signal Pathway > Apoptosis > Mdm2

Mdm2


Mouse double minute 2 homolog (MDM2) also known as E3 ubiquitin-protein ligase Mdm2 is a protein that in humans is encoded by the MDM2 gene. Mdm2 is an important negative regulator of the p53 tumor suppressor. Mdm2 protein functions both as an E3 ubiquitin ligase that recognizes the N-terminal trans-activation domain (TAD) of the p53 tumor suppressor and an inhibitor of p53 transcriptional activation.

  • Nutlin-3b EY1851

    Nutlin-3b是MDM2/p53抑制剂，IC50为13.6 μM。

    More

  • MI-773 EY1469

    MI-773是一种高效的选择性MDM2抑制剂, 与MDM2结合, Ki值为0.88 nM.

    More

  • YH239-EE EY1187

    YH239-EE是YH239的乙酯形式，是p53-MDM2的拮抗剂、凋亡诱导剂。

    More

  • NSC 207895 EY0361

    NSC 207895抑制MDMX，IC50为2.5 μM，促进p53稳定/激活和DNA损伤，也调节MDM2（E3连接酶）。

    More
    • Current page2, Total Pages2, Total Record9 First Prev 12 Next Last Goto
More