Rho
The Rho family of GTPases is a family of small (~21 kDa) signaling G proteins, and is a subfamily of the Ras superfamily. The members of the Rho GTPase family have been shown to regulate many aspects of intracellular actin dynamics, and are found in all eukaryotic kingdoms, including yeasts and some plants. Three members of the family have been studied in detail: Cdc42, Rac1, and RhoA. All G proteins are "molecular switches", and Rho proteins play a role in organelle development, cytoskeletal dynamics, cell movement, and other common cellular functions.
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Azathioprine (硫唑嘌呤; Azasan, Imuran; BW 57-322) 是免疫抑制剂。
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6H05是突变型原癌基因K-ras(G12C)选择性变构抑制剂。
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K-Ras(G12C) inhibitor 12是K-Ras(G12C)抑制剂, K-Ras(G12C) inhibitor 12作用于H1792细胞, EC50为0.32 μM。
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K-Ras(G12C) inhibitor 9 是致癌的K-Ras(G12C)的变构抑制剂。
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Zoledronic Acid 是一种有效的含氮双膦酸盐，抑制人胎儿成骨细胞（hFOB）增殖，IC50为40 μM。
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