RARs/RXR
RAR (The retinoic acid receptor) is a type of nuclear receptor which can also act as a transcription factor that is activated by both all-trans retinoic acid and 9-cis retinoic acid. There are three retinoic acid receptors (RAR), RAR-alpha, RAR-beta, and RAR-gamma. Each receptor isoform has several splice variants: four- for alpha, four- for beta, and two- for gamma. RXR (The retinoid X receptor) is a type of nuclear receptor that is activated by 9-cis retinoic acid. There are three retinoic X receptors (RXR): RXR-alpha, RXR-beta, and RXR-gamma. RXR heterodimerizes with subfamily 1 nuclear receptors including CAR, FXR, LXR, PPAR, PXR, RAR, TR, and VDR.
-
LE 135是选择性 RARβ 拮抗剂。
More
-
TTNPB 是RAR激动剂，对人RARα，β和γ的IC50分别为5.1 nM，4.5 nM和9.3 nM。
More
-
All-trans retinoic acid可作用于前列腺癌等众多癌症。
More
-
Adapalene (阿达帕林; CD-271; Differin) 是合成的维甲酸，为维甲酸受体（RAR）激动剂。
More
-
Tamibarotene是RARα激动剂，能诱导HL-60细胞体外分化和凋亡，ED50为0.79 nM。
More
