p38 MAPK
p38 MAPK are a class of mitogen-activated protein kinases (MAPKs) that are responsive to stress stimuli, such as cytokines, ultraviolet irradiation, heat shock, and osmotic shock, and are involved in cell differentiation, apoptosis and autophagy. p38 MAPK is the mammalian orthologue of the yeast Hog1p MAP kinase, which participates in a signaling cascade controlling cellular responses to cytokines and stress. Four p38 MAP kinases, p38-α (MAPK14), -β (MAPK11), -γ (MAPK12 / ERK6), and -δ (MAPK13 / SAPK4), have been identified. Similar to the SAPK/JNK pathway, p38 MAP kinase is activated by a variety of cellular stresses including osmotic shock, inflammatory cytokines, lipopolysaccharides (LPS), Ultraviolet light, and growth factors.
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SCIO 469 hydrochloride是选择性 p38 MAPK抑制剂。
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SB 706504是p38 MAPK 抑制剂。
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SB 239063是活性选择性 p38 MAPK 抑制剂，口服有效。
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RWJ 67657是活性的， 选择性 p38α 和 p38β 抑制剂。
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ML 3403是p38 抑制剂。
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