Dopamine Receptor
Dopamine receptors are a class of G protein-coupled receptors that are prominent in the vertebrate central nervous system. The neurotransmitter dopamine is the primary endogenous ligand for dopamine receptors. Dopamine receptors are implicated in many neurological processes, including motivation, pleasure, cognition, memory, learning, and fine motor control, as well as modulation of neuroendocrine signaling. Abnormal dopamine receptor signaling and dopaminergic nerve function is implicated in several neuropsychiatric disorders. Thus, dopamine receptors are common neurologic drug targets; antipsychotics are often dopamine receptor antagonists while psychostimulants are typically indirect agonists of dopamine receptors. There are at least five subtypes of dopamine receptors, D1, D2, D3, D4, and D5. The D1 and D5 receptors are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 receptors are members of the D2-like family.
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Amisulpride是选择性 D2/D3 受体拮抗剂， atypical antipsychotic agent。
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ABT 724 trihydrochloride是活性的， 选择性 D4 部分 激动剂， proerectile。
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A 77636 hydrochloride是活性的， 选择性 D1样激动剂。 口服有效。
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A 68930 hydrochloride是活性的， 选择性 D1样激动剂。
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A 412997 dihydrochloride是选择性 D4 激动剂。
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Amisulpride是选择性 D2/D3 受体拮抗剂， atypical antipsychotic agent。
More
-
ABT 724 trihydrochloride是活性的， 选择性 D4 部分 激动剂， proerectile。
More
-
A 77636 hydrochloride是活性的， 选择性 D1样激动剂。 口服有效。
More
-
A 68930 hydrochloride是活性的， 选择性 D1样激动剂。
More
-
A 412997 dihydrochloride是选择性 D4 激动剂。
More
