Dopamine Receptor
Dopamine receptors are a class of G protein-coupled receptors that are prominent in the vertebrate central nervous system. The neurotransmitter dopamine is the primary endogenous ligand for dopamine receptors. Dopamine receptors are implicated in many neurological processes, including motivation, pleasure, cognition, memory, learning, and fine motor control, as well as modulation of neuroendocrine signaling. Abnormal dopamine receptor signaling and dopaminergic nerve function is implicated in several neuropsychiatric disorders. Thus, dopamine receptors are common neurologic drug targets; antipsychotics are often dopamine receptor antagonists while psychostimulants are typically indirect agonists of dopamine receptors. There are at least five subtypes of dopamine receptors, D1, D2, D3, D4, and D5. The D1 and D5 receptors are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 receptors are members of the D2-like family.
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Haloperidol hydrochloride是拮抗剂， 部分 D2 选择性。
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GSK 789472 hydrochloride是D3 拮抗剂。 也是D2部分激动剂。
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GR 103691是高选择性 D3 拮抗剂。
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GBR 13069 dihydrochloride是活性的 dopamine uptake inhibitor（摄取抑制剂）。
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GBR 12935 dihydrochloride是选择性 dopamine uptake inhibitor（摄取抑制剂）。
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Haloperidol hydrochloride是拮抗剂， 部分 D2 选择性。
More
-
GSK 789472 hydrochloride是D3 拮抗剂。 也是D2部分激动剂。
More
-
GR 103691是高选择性 D3 拮抗剂。
More
-
GBR 13069 dihydrochloride是活性的 dopamine uptake inhibitor（摄取抑制剂）。
More
-
GBR 12935 dihydrochloride是选择性 dopamine uptake inhibitor（摄取抑制剂）。
More
