Dopamine Receptor
Dopamine receptors are a class of G protein-coupled receptors that are prominent in the vertebrate central nervous system. The neurotransmitter dopamine is the primary endogenous ligand for dopamine receptors. Dopamine receptors are implicated in many neurological processes, including motivation, pleasure, cognition, memory, learning, and fine motor control, as well as modulation of neuroendocrine signaling. Abnormal dopamine receptor signaling and dopaminergic nerve function is implicated in several neuropsychiatric disorders. Thus, dopamine receptors are common neurologic drug targets; antipsychotics are often dopamine receptor antagonists while psychostimulants are typically indirect agonists of dopamine receptors. There are at least five subtypes of dopamine receptors, D1, D2, D3, D4, and D5. The D1 and D5 receptors are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 receptors are members of the D2-like family.
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Amantadine hydrochloride是抗流感病毒和抗帕金森病化合物。
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Pramipexole 2HCl Monohydrate 是一种部分/全部D2S， D2L， D3， D4受体激动剂，Ki为3.9， 2.2， 0.5， 5.1 nM。
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Rotundine是一种选择性多巴胺D1受体拮抗剂， IC50为166 nM。
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Lurasidone HCl是一种非典型的抗精神病药物，抑制D2， 5-HT2A， 5-HT7， 5-HT1A和去甲肾上腺素α2C，IC50分别为1.68 nM， 2.03 nM， 0.495 nM， 6.75 nM和10.8 nM。
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Levosulpiride是Sulpiride的(S)对映体, 是多巴胺D2受体拮抗剂。
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Amantadine hydrochloride是抗流感病毒和抗帕金森病化合物。
More
-
Pramipexole 2HCl Monohydrate 是一种部分/全部D2S， D2L， D3， D4受体激动剂，Ki为3.9， 2.2， 0.5， 5.1 nM。
More
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Rotundine是一种选择性多巴胺D1受体拮抗剂， IC50为166 nM。
More
-
Lurasidone HCl是一种非典型的抗精神病药物，抑制D2， 5-HT2A， 5-HT7， 5-HT1A和去甲肾上腺素α2C，IC50分别为1.68 nM， 2.03 nM， 0.495 nM， 6.75 nM和10.8 nM。
More
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Levosulpiride是Sulpiride的(S)对映体, 是多巴胺D2受体拮抗剂。
More
