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Adrenergic Receptor


The adrenergic receptors (or adrenoceptors) are a class of G protein-coupled receptors that are targets of the catecholamines, especially norepinephrine (noradrenaline) and epinephrine (adrenaline). Epinephrine (adrenaline) reacts with both α- and β-adrenoreceptors, causing vasoconstriction and vasodilation, respectively. High levels of circulating epinephrine cause vasoconstriction. At lower levels of circulating epinephrine, β-adrenoreceptor stimulation dominates, producing vasodilation followed by decrease of peripheral vascular resistance.
Many cells possess these receptors, and the binding of a catecholamine to the receptor will generally stimulate the sympathetic nervous system. The sympathetic nervous system is responsible for the fight-or-flight response, which includes dilating the pupils, increasing heart rate, mobilizing energy, and diverting blood flow from non-essential organs to skeletal muscle. 

  • Silodosin EY2258

    Silodosin(Rapaflo) is an α1-adrenoceptor antagonist with high uroselectivity. Silodosin causes practically no orthostatic hypotension (in contrast to other α1 blockers). Since Silodosin is a highly selective inhibitor of the α1A adrenergic receptor, it causes practically no orthostatic hypotension (in contrast to other α1 blockers).

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  • Tizanidine HCl EY2245

    Tizanidine HCl is a skeletal muscle relaxant. It is an α2-adrenergic receptor agonist and inhibits neurotransmitter release from CNS noradrenergic neurons.

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  • Asenapine EY2232

    Asenapine inhibits adrenergic receptor (α1, α2A, α2B, α2C) with Ki of 0.25-1.2 nM and also inhibits 5-HT receptor (1A, 1B, 2A, 2B, 2C, 5A, 6, 7) with Ki of 0.03-4.0 nM.

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  • ICI 118，551 hydrochloride EI1327

    ICI 118，551 hydrochloride是高选择性 β2 拮抗剂。

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  • Idazoxan hydrochloride EI1332

    Idazoxan hydrochloride是α2 拮抗剂。 也是I2 配体。

    More

  • Silodosin EY2258

    Silodosin(Rapaflo) is an α1-adrenoceptor antagonist with high uroselectivity. Silodosin causes practically no orthostatic hypotension (in contrast to other α1 blockers). Since Silodosin is a highly selective inhibitor of the α1A adrenergic receptor, it causes practically no orthostatic hypotension (in contrast to other α1 blockers).

    More

  • Tizanidine HCl EY2245

    Tizanidine HCl is a skeletal muscle relaxant. It is an α2-adrenergic receptor agonist and inhibits neurotransmitter release from CNS noradrenergic neurons.

    More

  • Asenapine EY2232

    Asenapine inhibits adrenergic receptor (α1, α2A, α2B, α2C) with Ki of 0.25-1.2 nM and also inhibits 5-HT receptor (1A, 1B, 2A, 2B, 2C, 5A, 6, 7) with Ki of 0.03-4.0 nM.

    More

  • ICI 118，551 hydrochloride EI1327

    ICI 118，551 hydrochloride是高选择性 β2 拮抗剂。

    More

  • Idazoxan hydrochloride EI1332

    Idazoxan hydrochloride是α2 拮抗剂。 也是I2 配体。

    More
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