Adrenergic Receptor
The adrenergic receptors (or adrenoceptors) are a class of G protein-coupled receptors that are targets of the catecholamines, especially norepinephrine (noradrenaline) and epinephrine (adrenaline). Epinephrine (adrenaline) reacts with both α- and β-adrenoreceptors, causing vasoconstriction and vasodilation, respectively. High levels of circulating epinephrine cause vasoconstriction. At lower levels of circulating epinephrine, β-adrenoreceptor stimulation dominates, producing vasodilation followed by decrease of peripheral vascular resistance.
Many cells possess these receptors, and the binding of a catecholamine to the receptor will generally stimulate the sympathetic nervous system. The sympathetic nervous system is responsible for the fight-or-flight response, which includes dilating the pupils, increasing heart rate, mobilizing energy, and diverting blood flow from non-essential organs to skeletal muscle.
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Mirabegron(YM178)是β3肾上腺素受体激动剂，EC50为22.4 nM。
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Terbutaline Sulfate是一种选择性的β2-肾上腺素能受体激动剂，IC50为53 nM。
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Metoprolol是心脏选择性β1肾上腺素阻断剂。
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Detomidine HCl是α2-肾上腺素激动剂。
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Salmeterol xinafoatexinafoate是长效β2肾上腺素受体激动剂，可作用于哮喘和慢性阻塞性肺病。
More
-
Mirabegron(YM178)是β3肾上腺素受体激动剂，EC50为22.4 nM。
More
-
Terbutaline Sulfate是一种选择性的β2-肾上腺素能受体激动剂，IC50为53 nM。
More
-
Metoprolol是心脏选择性β1肾上腺素阻断剂。
More
-
Detomidine HCl是α2-肾上腺素激动剂。
More
-
Salmeterol xinafoatexinafoate是长效β2肾上腺素受体激动剂，可作用于哮喘和慢性阻塞性肺病。
More
