Akt
Akt (Protein kinase B (PKB)) is a serine/threonine-specific protein kinase that plays a key role in multiple cellular processes such as glucose metabolism, apoptosis, cell proliferation, transcription and cell migration.
Akt regulates cellular survival and metabolism by binding and regulating many downstream effectors, e.g. Nuclear Factor-κB, Bcl-2 family proteins and MDM2.
Akt could promote growth factor-mediated cell survival both directly and indirectly. BAD is a pro-apoptotic protein of the Bcl-2 family. Akt could phosphorylate BAD on Ser136, which makes BAD dissociate from the Bcl-2/Bcl-X complex and lose the pro-apoptotic function. Akt could also activate NF-κB via regulating IκB kinase (IKK), thus result in transcription of pro-survival genes.
Akt1 has also been implicated in angiogenesis and tumor development.
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Miltefosine作用于癌细胞系A431和HeLa，抑制PI3K/Akt活性，ED50分别为17.2 μM和8.1 μM，是第一个用于治疗内脏利什曼病的口服药物，有效对抗前鞭毛体和无鞭毛体。
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TIC10是口服活性的稳定化合物，能抑制Akt和ERK，能透过血脑屏障，可诱导TRAIL。
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SC79是一个独特的特异性Akt激动剂, 可用于在各种生理和病理条件增强Akt活性。
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PHT-427是作用于Akt和PDPK1的双重抑制剂，Akt和PDPK1的PH结构域具有高度亲和力，Ki分别为2.7 μM和5.2 μM。
More
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Miltefosine作用于癌细胞系A431和HeLa，抑制PI3K/Akt活性，ED50分别为17.2 μM和8.1 μM，是第一个用于治疗内脏利什曼病的口服药物，有效对抗前鞭毛体和无鞭毛体。
More
-
TIC10是口服活性的稳定化合物，能抑制Akt和ERK，能透过血脑屏障，可诱导TRAIL。
More
-
SC79是一个独特的特异性Akt激动剂, 可用于在各种生理和病理条件增强Akt活性。
More
-
PHT-427是作用于Akt和PDPK1的双重抑制剂，Akt和PDPK1的PH结构域具有高度亲和力，Ki分别为2.7 μM和5.2 μM。
More
